What is the blood test for mental health?

Asked by: Santina Ebert  |  Last update: February 13, 2026
Score: 4.6/5 (75 votes)

Blood tests for mental health help rule out physical causes (like thyroid issues, deficiencies, infections) and can offer insights into inflammation or genetics, but they don't diagnose disorders directly; instead, they support clinical assessment, guide treatment by checking medication response (pharmacogenomics), and monitor overall health, with research progressing on novel biomarker tests for conditions like depression and psychosis.

What blood tests are done for mental health?

MindX Blood Tests, which uses gene expression profiling by RNA sequencing of genes collected from whole blood to assess, predict or manage mood disorders, stress disorders, suicidality, longevity/mortality, and pain associated with depression or substance use history: MindX - Longevity. MindX - Mood disorders.

What blood test is done for anxiety?

Adrenal Stress Test

A test to analyze the cortisol (primary stress hormone) levels can identify the underlying factors related to stress and anxiety. The adrenal stress test assesses the function of the adrenal glands. The adrenal glands secrete cortisol and other hormones that regulate stress and other body functions.

What blood tests detect brain problems?

The Lumipulse test uses a blood sample drawn at the doctor's office. The test measures certain proteins, including a specific form of the tau protein, that can indicate the presence of amyloid plaques in the brain. An amyloid plaque is a buildup of protein that is considered the hallmark sign of Alzheimer's disease.

Why do I need a blood test for mental health?

Blood tests can be helpful when your psychiatrist's making a mental health diagnosis by ruling out pre-existing physical disorders. Finding out you have an existing physical disorder might also influence which medications are safe to take.

Basic Labs for Mental Health Assessment

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Will insurance cover a GeneSight test?

Medicaid - Typically, you will have a $0 out of pocket cost. Commercial or Other Insurance - Plans vary, but you may be expected to cover a portion of the cost (typically $330 or less) and the GeneSight Promise applies. It will likely be several months before you receive a bill from us.

What are 5 signs your brain is in trouble?

Five key signs your brain might be in trouble include sudden confusion/memory issues, difficulty with speech or vision, severe, unexplained headaches, major changes in mood or personality, and problems with balance, coordination, or numbness, especially if they appear suddenly or worsen, requiring prompt medical attention.
 

Do neurological disorders show up in blood work?

What blood tests show neurological issues? Blood tests that check Vitamin B12, thyroid hormones, and blood sugar levels can help find the causes of neurological problems. Other tests include markers for inflammation, autoimmune diseases, and toxins that may affect nerves.

What are the 5 main blood tests?

The 5 main blood tests that offer a broad health overview are the Complete Blood Count (CBC), which checks blood cells; the Comprehensive Metabolic Panel (CMP), assessing organ function and electrolytes; the Lipid Panel, for heart disease risk; the Thyroid Panel (TSH), checking metabolism; and a Blood Glucose/A1C, monitoring diabetes, giving insights into infection, organ health, heart risk, and sugar levels. 

Can stress show up in a blood test?

A blood test can evaluate stress-related biomarkers to assess your adrenal function and rule out the development of adrenal disorders.

Do psychiatrists do blood tests?

Psychiatrists often order investigations such as blood tests, neuroimaging and electroencephalograms for their patients.

What hormone is tested for anxiety?

A cortisol test measures the level of cortisol in your blood, pee or spit. You often need to get multiple cortisol tests because your levels naturally change throughout the day.

What are the 5 D's of mental illness?

The "5 Ds of mental illness" are a framework for understanding abnormal behavior, typically including Deviance, Distress, Dysfunction, Duration, and Danger, used by clinicians to determine if a pattern of thoughts, feelings, or behaviors crosses the line from normal human experience to a diagnosable disorder, often adding Duration, Degree, or sometimes even Disability to the common Four Ds (Deviance, Distress, Dysfunction, Danger). These criteria help assess if symptoms are significantly outside cultural norms (Deviance), cause significant suffering (Distress), impair daily life (Dysfunction), persist over time (Duration), and pose a risk to self or others (Danger). 

What are the most important lab markers for mental health?

Common Lab Tests That Support Mental Health Assessment

Vitamin B12 and B9: Low levels may be linked to depression and cognitive issues. Vitamin D: Deficiency is associated with seasonal mood disorders and depression.

How do I get my mental health tested?

A GP or nurse may refer you for a mental health assessment. Social care services or educational services also sometimes refer people. You'll have a detailed mental health assessment, which will usually be carried out by a specialist mental health doctor (psychiatrist).

Can blood tests show brain problems?

Researchers are now developing biomarker tests that can detect two proteins called amyloid or tau proteins in the blood. These proteins both build up in the brain in Alzheimer's disease, and when detected in blood could be used to indicate that they are also present in the brain.

What are red flag neurological symptoms?

Neurological red flags are serious signs like sudden severe headaches, one-sided weakness or numbness, slurred speech, vision loss, confusion, or seizures, indicating a potential medical emergency like a stroke, brain tumor, or meningitis, and require immediate medical attention for proper diagnosis and treatment. Other warning signs include persistent dizziness, balance problems, sudden memory loss, personality changes, tremors, or loss of developmental skills in children. 

What are signs of poor brain function?

Symptoms of the brain not working properly often involve "brain fog," including memory issues, trouble focusing, mental fatigue, slow thinking, word-finding difficulty, confusion, poor judgment, and mood changes like anxiety or irritability, alongside potential sleep problems, headaches, or lack of motivation. These can stem from stress, poor sleep, lifestyle factors, or underlying conditions like mild cognitive impairment, trauma, or neurological disorders. 

What are the first signs of a neurological disorder?

Early symptoms of neurological disorders vary but often include persistent headaches, numbness/tingling, muscle weakness or coordination issues, balance problems, dizziness, vision/speech changes, memory loss, confusion, tremors, and seizures, requiring prompt medical evaluation for effective treatment.
 

What vitamin deficiency is linked to dementia?

Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease.

What are the first warning signs of a brain tumor?

Early warning signs of a brain tumor include new or worsening headaches (especially in the morning), seizures, persistent nausea/vomiting, vision changes (blurry, double vision, loss of peripheral), and unexplained personality/behavior shifts (memory loss, confusion, mood swings) or weakness/numbness, often appearing as new or worsening neurological issues that don't resolve.
 

What is the first stage of a mental breakdown?

The first stage of a mental breakdown, often called the onset or honeymoon phase, involves subtle signs like increased stress, irritability, sleep changes (insomnia or oversleeping), appetite shifts, fatigue, difficulty concentrating, and pulling away from social activities, as your body starts showing stress before a full crisis, signaling a gradual depletion of emotional resources.
 

What are the 3 C's of mental illness?

The 3 C's of CBT, Catching, Checking and Changing, serve as practical steps for people to manage their thoughts and behaviors. These steps help you to recognize and alter negative patterns that contribute to mental health issues and substance abuse.

What is the hardest mental illness to live with?

There's no single "hardest" mental illness, as experiences vary, but Schizophrenia, Borderline Personality Disorder (BPD), Bipolar Disorder, and severe Eating Disorders (like Anorexia Nervosa) are often cited as extremely challenging due to their profound impact on reality, emotions, relationships, and daily functioning, often involving symptoms like psychosis, severe mood swings, intense instability, and distorted self-perception.