What is the two-step approach glucose challenge test?
Asked by: Dean Beahan PhD | Last update: January 31, 2026Score: 4.9/5 (29 votes)
The two-step approach for gestational diabetes (GDM) screening involves a non-fasting 50-gram Glucose Challenge Test (GCT) as Step 1; if results are high (e.g., >130-140 mg/dL), Step 2 is a diagnostic 100-gram, three-hour Oral Glucose Tolerance Test (OGTT), with GDM diagnosed if two or more values exceed thresholds. Recommended by the American College of Obstetricians and Gynecologists (ACOG) (ACOG), this method is convenient as Step 1 doesn't require fasting, but it sends many women to the longer diagnostic test.
What is the 2 step approach for gestational diabetes?
25 In the two-step approach, a screening test is initially performed using 50-g glucose; thereafter, a 3-hour 100-g OGTT is performed for those with positive results. To establish a diagnosis, patients must come to the hospital for a second visit.
Which is better one step or two-step gestational diabetes testing?
In an RCT meta-analysis of three studies, it is shown that the prevalence of GDM in both One- and Two-step approaches were similar (8.4% vs. 4.3%; relative risk 1.64, 95% CI, 0.77–3.48 and the One-step approach was associated with better maternal and perinatal outcomes (18).
How do they do the glucose challenge test?
Do not eat or drink anything (other than sips of water) for 8 to 14 hours before your test. (You also cannot eat during the test.) You will be asked to drink a liquid that contains 75 grams of glucose. You will have blood drawn before you drink the liquid, and again 2 more times every 60 minutes after you drink it.
What is a 2hr glucose tolerance test?
You drink a syrupy glucose solution that has 75 grams of sugar. One hour later and two hours later, samples of your blood are taken. The blood sugar levels are measured.
OG capsule #4 ACOG - Two step Screening Test for GDM
What are 5 signs your blood sugar is too high?
Symptoms of hyperglycaemia include:
- increased thirst and a dry mouth.
- needing to pee frequently.
- tiredness.
- blurred vision.
- unintentional weight loss.
- recurrent infections, such as thrush, bladder infections (cystitis) and skin infections.
Can I be hypoglycemic but not diabetic?
Reactive hypoglycaemia
People without diabetes can sometimes experience hypoglycaemia if their pancreas produces too much insulin after a large carbohydrate-based meal. This is known as reactive hypoglycaemia.
How does GD affect my baby?
Gestational diabetes (GD) can make a baby grow too large (macrosomia), increasing birth injury risk, and cause immediate issues like low blood sugar (hypoglycemia), breathing problems, and jaundice after birth. Long-term, babies face a higher risk of obesity, high blood pressure, and type 2 diabetes as they grow. Proper management of blood sugar during pregnancy significantly reduces these risks.
How accurate is the glucose challenge?
For studies with a high risk population sensitivity was 74% (95% CI 62 to 87), specificity was 77% (95% CI 66 to 89), positive likelihood ratio was 3.2 (95% CI 2.0 to 5.2) and negative likelihood ratio was 0.34 (95% CI 0.22 to 0.53).
What is the difference between GTT and GCT?
GCT screens quickly with a one-hour blood sugar check after a glucose drink. GTT is a more extended test with fasting, a glucose drink, and multiple blood sugar checks over hours to confirm diabetes and assess glucose tolerance comprehensively.
What week is the hardest for gestational diabetes?
The hardest part of gestational diabetes (GD) for many is the peak insulin resistance, usually between 32 to 36 weeks, when the placenta's hormones are strongest, making blood sugar control difficult and often requiring more medication, though the initial weeks after diagnosis (24-28 weeks) are also tough due to lifestyle adjustments, with some finding the late stages (around 36-37+ weeks) challenging as the placenta ages and levels can fluctuate dramatically.
What can throw off a gestational diabetes test?
Most pregnancy care providers recommend avoiding foods high in sugar for breakfast. For example, pancakes, donuts or juice. If you're testing later in the day, be aware that eating large amounts of sugar for lunch may affect your results.
What's the most accurate test for diabetes?
The most accurate test for diagnosing diabetes depends on the situation, but the Hemoglobin A1C test (HbA1c) is often preferred for its reliability in showing average blood sugar over 2-3 months, while the Fasting Plasma Glucose (FPG) and Oral Glucose Tolerance Test (OGTT) are also standard, often used with FPG on two separate days or for confirmation. The A1C reflects long-term control, whereas FPG and OGTT measure immediate sugar levels, with FPG needing fasting and OGTT involving a sugary drink after fasting.
What are the warning signs of gestational diabetes?
See your GP if you develop symptoms of high blood sugar, such as increased thirst, needing to pee more often than usual, and a dry mouth – do not wait until your next test. You should have the tests even if you feel well, as many people with diabetes do not have any symptoms.
How common is it to fail the 1 hour glucose test?
Failing the 1-hour glucose screening test is quite common, with about 15% to 25% of pregnant people getting an abnormal result, but this doesn't automatically mean you have gestational diabetes; it's a screening to see if you need the more definitive 3-hour glucose tolerance test (GTT). Most people who "fail" the initial screen actually pass the longer GTT, as the 1-hour test has a low threshold to catch potential issues, and a result above 140 mg/dL often triggers the next step.
Does stress contribute to gestational diabetes?
According to the CDC, 2-10% of pregnant women suffer from diabetes during pregnancy every year. A woman who is already stressed or has anxiety issues is at a high risk of gestational diabetes.
What week is gestational diabetes most common?
Gestational diabetes usually develops around the 24th week of pregnancy. You'll probably be tested between 24 and 28 weeks. If you're at higher risk for gestational diabetes, your doctor may test you earlier. If your blood sugar is higher than normal early in your pregnancy, you may not have gestational diabetes.
How can I lower my risk of gestational diabetes?
You can significantly lower your risk of gestational diabetes through lifestyle changes like eating a diet rich in fiber (fruits, veggies, whole grains), limiting sugar and processed foods, exercising regularly (e.g., brisk walking), staying hydrated, managing weight before pregnancy, and avoiding excessive weight gain during pregnancy, all while consulting your doctor for personalized guidance.
What can throw off a fasting glucose test?
Fasting blood sugar tests are affected by what you eat/drink (except water) before the fast, stress, illness, lack of sleep, certain medications (like steroids), dehydration, and even the timing of your last meal or exercise, with issues like the Dawn Phenomenon causing natural nighttime rises, all impacting results by raising or lowering glucose levels from your true baseline.
Is GD a high risk pregnancy?
Yes, gestational diabetes (GDM) is considered a high-risk pregnancy because it increases the risk of complications for both parent and baby, such as preeclampsia, preterm birth, larger baby (macrosomia), and needing a C-section, though most pregnancies with GDM are healthy when managed well with blood sugar control. Close monitoring and management through diet, exercise, and sometimes medication are crucial to lower these risks.
What foods should you avoid with gestational diabetes?
With gestational diabetes, avoid sugary drinks, sweets, refined grains (white bread, white rice), processed foods, and unhealthy fats, as they spike blood sugar; instead, focus on whole foods, lean proteins, and high-fiber options, managing portions of carbohydrates like fruits, starchy vegetables, and whole grains, and always limit alcohol and foods high in saturated/trans fats.
Do you get more ultrasounds if you have GD?
Because of this, you'll be offered extra antenatal appointments so your baby can be monitored. Appointments you should be offered include: an ultrasound scan at around week 18 to 20 of your pregnancy to check your baby for abnormalities.
What foods trigger hypoglycemia?
Foods that cause reactive hypoglycemia, or low blood sugar after eating, are typically high in simple carbohydrates and sugar, leading to a rapid insulin spike and subsequent crash, including items like white bread, potatoes, sugary drinks, pastries, and candy; alcohol, especially without food, and even skipping meals can also trigger lows. Complex carbs, protein, and fiber help stabilize blood sugar, so eating them in balanced meals, rather than just simple sugars, prevents dramatic drops.
What A1c is too low?
Low hemoglobin A1c (<4.0%) was associated with an increased risk of all-cause mortality. Other biological processes, such as inflammation and liver function, may underlie the association between low hemoglobin A1c (<4.0%) and all-cause mortality.
What does a blood sugar spike feel like?
A blood sugar spike feels like a mix of sudden energy (sugar rush) followed by a crash, causing fatigue, brain fog, irritability, increased thirst, frequent urination, hunger, headaches, and sometimes blurry vision or nausea, as your body struggles to process the excess sugar, leading to energy fluctuations and stress.