What are the examples of intraperitoneal drugs?

Asked by: Noemie Adams  |  Last update: February 20, 2026
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Examples of intraperitoneal (IP) drugs primarily include anticancer agents like cisplatin, paclitaxel, doxorubicin, mitomycin C, and oxaliplatin, used for cancers like ovarian, gastric, and colorectal, often in Hyperthermic Intraperitoneal Chemotherapy (HIPEC). Other IP drugs can include antibiotics (like cefazolin, gentamicin) and anesthetics (like ketobemidone) for different conditions, administered directly into the abdominal cavity for targeted treatment.

What drugs are intraperitoneal?

Drugs most commonly applied for intraperitoneal chemotherapy include mitomycin C, cisplatin, carboplatin, oxaliplatin, irinotecan, 5-fluoruracil, gemcitabine, paclitaxel, docetaxel, doxorubicin, premetrexed and melphalan. The drugs and their doses that are used vary widely among centres.

What drugs are given by intraperitoneal route?

Use in humans. Currently, there are a handful of drugs that are delivered through intraperitoneal injection for chemotherapy. They are mitomycin C, cisplatin, carboplatin, oxaliplatin, irinotecan, 5-fluorouracil, gemcitabine, paclitaxel, docetaxel, doxorubicin, premetrexed, and melphalan.

What is considered intraperitoneal?

Your parietal peritoneum lines the walls of this cavity. Your visceral peritoneum wraps around your abdominal organs, particularly your stomach, liver, spleen and parts of your small and large intestines. Organs inside of your visceral peritoneum are called “intraperitoneal.” The others are “retroperitoneal.”

What is an IP drug?

Definition. Intraperitoneal (IP) chemotherapy is a medical treatment that involves the administration of chemotherapeutic drugs directly into the peritoneal cavity.

TIPSS, Transjugular Intrahepatic Porto-Systemic Shunt

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What medication is IP?

The IP 109 White Oval Pill

The IP 109 pill is a Schedule II prescription medication that combines two active ingredients: hydrocodone and acetaminophen. Together, they provide pain relief for individuals suffering from moderate to severe conditions.

How is intraperitoneal administered?

The fluid and medication mixture will be in a bag that's attached to the needle. It will be injected directly into your peritoneal space through your access port. This mixture will flow into your peritoneal space. You may need to have more fluid placed into your IV after your treatment.

What organs are not intraperitoneal?

Primarily retroperitoneal organs developed and remain outside of the parietal peritoneum. The oesophagus, rectum and kidneys are all primarily retroperitoneal. Secondarily retroperitoneal organs were initially intraperitoneal, suspended by mesentery.

What are common intraperitoneal diseases?

PRIMARY DISEASES OF THE PERITONEUM

  • Peritoneal pseudomyxoma.
  • Malignant peritoneal mesothelioma.
  • Peritoneal inclusion cysts or formerly cystic mesothelioma of the peritoneum.
  • Disseminated peritoneal leiomyomatosis.
  • Primary peritoneal carcinoma.
  • Small cell desmoplastic tumor.

Are kidneys intraperitoneal?

The kidneys are paired retroperitoneal organs located between the T12 and L3 vertebrae, positioned lateral to the spine and adjacent to multiple abdominal structures.

What are intraperitoneal antibiotics?

IP antibiotic therapy ensures maximal antibiotic concentrations in the peritoneal cavity, which is the principal site of infection. In clinical practice, antibiotics are added to the PD solution and allowed to dwell in the peritoneal cavity for at least 6 hours while performing continuous ambulatory PD (CAPD).

What are the 4 examples of drugs that can be administered parenterally?

The parenteral route of drug delivery includes four types: subcutaneous, intramuscular, intravenous, and intrathecal administration. Examples of medications delivered parenterally include insulin, opioid analgesics, vaccines, and antibiotics, amongst other drugs.

What does IP mean in medicine?

I.P., the abbreviation of 'Indian Pharmacopoeia' is familiar to the consumers in the Indian sub-continent as a mandatory drug name suffix. Drugs manufactured in India have to be labelled with the mandatory non-proprietary drug name with the suffix I.P.

What are the five retroperitoneal organs?

The area in the back of the abdomen behind the peritoneum (the tissue that lines the abdominal wall and covers most of the organs in the abdomen). The organs in the retroperitoneum include the adrenal glands, aorta, kidneys, esophagus, ureters, pancreas, rectum, and parts of the stomach and colon.

Which antibiotic is best for abdominal infection?

There's no single "best" antibiotic for a stomach infection; it depends on the specific bacteria causing it, but common options for severe bacterial cases include Azithromycin, Ciprofloxacin, Rifaximin, Levofloxacin, and Metronidazole, though many mild infections resolve on their own, and antibiotics don't work for viruses. A doctor must diagnose the cause (e.g., Salmonella, E. coli, H. pylori) to prescribe the right antibiotic, like Amoxicillin for H. pylori or fluoroquinolones for traveler's diarrhea. 

Can ceftriaxone be given intraperitoneal?

Over 72 hours only 5.5% of the dose was eliminated by the peritoneal route. After intraperitoneal administration, ceftriaxone rapidly appeared in serum; the absorption t1/2 was 1.1 h and the mean peak concentration was 38.8 micrograms/ml. The absorption of ceftriaxone from the peritoneal space was 39%.

Which organs are intraperitoneal?

The peritoneum is comprised of 2 layers: the superficial parietal layer and the deep visceral layer. The peritoneal cavity contains the omentum, ligaments, and mesentery. Intraperitoneal organs include the stomach, spleen, liver, first and fourth parts of the duodenum, jejunum, ileum, transverse, and sigmoid colon.

What are the big 4 of peritonitis?

The "Big Four" warning signs for peritonitis, a serious abdominal inflammation, are severe abdominal pain, tenderness/rigidity (guarding), bloating/distention, and nausea/vomiting, often accompanied by fever and inability to pass gas or stool, signaling a medical emergency requiring immediate attention. 

What are the signs of intraperitoneal infection?

They may include:

  • Severe belly pain that gets worse with any motion.
  • Nausea and vomiting.
  • Fever.
  • Sore or swollen belly.
  • Fluid in the belly.
  • Not being able to have a bowel movement or pass gas.
  • Less urine than normal.
  • Thirst.

What cancers spread to the peritoneum?

Cancers that commonly spread to the peritoneum (lining of the abdomen) include ovarian, colorectal, stomach, pancreatic, and appendix cancer, often forming peritoneal carcinomatosis. Other less common sources include lung, breast, skin cancer, neuroendocrine tumors, and gastrointestinal stromal tumors (GISTs). This spread happens when cancer cells detach from a primary tumor and travel through the abdominal cavity.
 

Which colon is intraperitoneal?

Intraperitoneal organs are completely surrounded by peritoneum and are therefore mobile. Of the colon, the ascending colon, descending colon and rectum are retroperitoneal, while the cecum, appendix, transverse colon and sigmoid colon are intraperitoneal.

What is the lining of your stomach called?

The mucosa is the inner layer. It may be called the stomach lining. It contains glands that produce enzymes and acid to help digest food.

How to give intraperitoneal antibiotics?

Inject the medicine into dialysate bag

Carefully remove cap from the syringe needle. Inject each dialysate bag with the prescribed dose of medication per dialysate bag using the medication syringe with needle attached. Gently shake each dialysate bag to mix the medicine evenly. Repeat for each dose of medication.

What does intraperitoneal mean in medical terms?

(IN-truh-PAYR-ih-toh-NEE-ul) Within the peritoneal cavity (the area that contains the abdominal organs).

What is the intraperitoneal drug route?

Intraperitoneal injection is widely used in rodents as a route of drug administration. Intraperitoneally applied drug forms are supposed to be located in the peritoneal cavity. The disappearance of drugs from the peritoneal cavity upon injection is because of diffusion into the surrounding tissues.